【轉載】歐亞遺傳地勢與維吾爾族的群體混合

ningbauning

关于两篇附件的讨论正在热战中啊！期待ing。。

http://comonca.org.cn/lh/Documents/A49S1.pdf
http://comonca.org.cn/lh/Documents/A49S1.xls

****************

91[A50] Li Hui, Cho Kelly, Kidd Judith R, Kidd Kenneth K (2009) Genetic Landscape of Eurasia Viewed from Large Allele Frequency Differences. The American Society of Human Genetics 59th Annual Meeting, Honolulu, Hawaii, October 20-24, 2009. No. 632/W, Poster 290. 李辉,赵艺憬,吉珠,吉坎(2009)等位基因频率高度差异体现的欧亚遗传地势. 美国人类遗传学会第59届年会.夏威夷, 檀香山, 2009年10月20-24日. No.630/W, 290.

          [PDF全文下载] [摘要]

Genetic Landscape of Eurasia Viewed from Large Allele Frequency Differences. H. Li, K. Cho, J. R. Kidd, K. K. Kidd Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520.

   The diversification leading to modern human populations in Eurasia is one of the most important topics in the study of human expansions after leaving Africa. Most studies of Eurasia populations have used either limited markers or involved insufficient population coverage. We chose 68 markers based on large allele frequency differences among a few Eurasian populations and then typed them on 1766 individuals from 34 populations representing all subdivisions of Eurasia. Analyses using the STRUCTURE program showed a clinal east-west division when K=2, with a median border dividing Central Asia along the Ob River, the Kazakh highland, the western side of Pamir Mountains, and the southwestern side of the Himalayas. We fit curves to the STRUCTURE loadings using distances of the population coordinates from the median border. The genetic structure changed dramatically only within 2000km on each side of the border. At higher values of K the western populations of East Asia are the first to be distinguished (at K=3): Mongols, Tibetans, Qiang, and Baima, are most distinct from the more eastern populations. At K=4 Southwest and South Asians are distinguished from the Europeans; At K=5 Southeast Asians and at K=6 Central Asians are successively distinguished from eastern East Asians. Several more isolated populations such as Samaritans, Atayals, or Micronesians were distinguished in different independent runs when K=7 providing no clear anthropological information. South Asians were always clustered with Southwest Asians with pronounced similarity to Central Asians. The failure to distinguish South Asians maybe due to the selection of the markers with large allele frequency differences specifically between Europeans and East Asians. We also tested for statistical differences in the allele frequencies for all pairs of clusters when K=6. The results showed significant borders (P<0.0001) including those between western East Asians and eastern East Asians or Central Asians; however, insignificant borders were observed between Southwest Asians and Southeast Asians or western East Asians, neither was between Central Asians and eastern East Asians. This indicates substantial gene flow in North Asia between eastern East Asians and Central Asians, and in South Asia between South Asians and Southeast Asians. Using increased population and marker coverage, this study helps to understand the details of genetic diversity and landscape of Eurasians.

ningbauning

很牛比的一幅SNP聚类图。。

circa

原文叻啥地方，發個鏈接來啊

寒寒豆

英文不好，谁能翻译一下大意

热度

看弗懂

JoJo

不是基因学专业的，我试着翻翻看吧。这段论文的大致意思应该是： 根据不同的K值（某个等位基因？），区分欧亚人群。 当K=3，蒙古，藏，羌，Baima（？）与更东面的人群有最明显的差别。 当K=4，西南亚和南亚人区别于欧洲人。当K＝5，东南亚人区别于东面的东亚人。当K＝6，中亚人区别于东面的东亚人。南亚人与西南亚人归到同一组，他们与中亚人相似。 不能区分出南亚人可能是因为marker的选择，特别是欧洲人与东亚人间较大的等位基因频率的差别。 当K＝6时，我们也测试了每一对人群在等位基因上的统计差别。结果显示在西面的东亚人和东面的东亚人或中亚人间有重要的边界。但是，西南亚人和东南亚人或西面的东亚人之间的边界不清，中亚人和东面的东亚人也如此。 这意味着在北亚，东面的东亚人和中亚人有实质的基因流，在南亚的南亚人和东南亚人之间也是如此。

翻译是件痛苦的事，我自己看不懂我翻的东西。  老实说，中文在科技类的论文中是有劣势的。

［ 本帖最后由 JoJo 于 2010-03-10 13:52:00 编辑 ］